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Archive for the ‘Epigenetics’ Category

Otto Warburg published his Nobel lecture in 1931 and said, with the directness that won him the prize: 

“Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause.

Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar.”

For forty years, his work was the leading framework for understanding cancer.

Then the genetic mutation theory emerged. Oncogenes. Tumour suppressor genes. DNA damage. The molecular biology of cancer became the dominant research paradigm from the 1970s onward.

Warburg’s metabolic theory was not disproven. It was superseded by a framework that had more funding and more pharmaceutical applications.

The problem: the genetic mutation theory has driven cancer research and treatment for fifty years. The outcomes have been mixed. For some cancers: certain leukaemias, some lymphomas, targeted therapies have been transformative. For solid tumours, the majority of cancer burden, five-year survival rates have improved modestly in many cases, barely at all in others.

Meanwhile, Thomas Seyfried at Boston College has published extensively arguing that cancer’s genetic mutations are downstream of metabolic dysfunction: that the mitochondrial impairment Warburg identified is the primary event, and that the mutations are a consequence, not the cause.

His book “Cancer as a Metabolic Disease” (2012) is one of the most important unread books in oncology.

The practical implications if Seyfried and the neo-Warburgian school are right:

Starving tumours of glucose, through therapeutic ketosis, directly targets their primary metabolic vulnerability.

Providing ketones as an alternative fuel gives normal cells a metabolic advantage over cancer cells, which largely cannot use them.

The combination of caloric restriction and ketogenic diet has shown striking results in animal models.

Human case reports of tumour regression on ketogenic protocols as adjuncts to standard treatment are documented.

The therapy requires no patent.

It requires food choices.

It may be most effective in combination with standard treatment.

The research funding to test it properly has not materialised.

Nobody is getting rich from telling cancer patients to stop eating sugar and start eating beef.

The people getting rich are selling the glucose-based IV nutrition that goes into cancer patients in hospitals, the corticosteroids that raise blood glucose, and the drugs that manage the disease rather than the environment in which it thrives.

Warburg was right in 1924.

The evidence that he was right has been accumulating for a century.

The clinical application has not followed the evidence.

The clinical application follows the money.

Every time.

Source: https://x.com/SamaHoole/status/2026690777749844257?s=20 

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Source: YouTube

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BruceChaos1The Truth about ‘Chaos’

If you have watched the news lately, browsed the web, or even looked out the window, you may have noticed that something is going on. In the face of economic upheaval, religious violence, racial bloodshed, climate change and now, a viral pandemic, civilization is in a state of upheaval. The globe is enveloped in chaos.

Chaos? That sounds pretty scary! The reason is that most people confuse the word chaos with the word random. Random simply means the outcome or result of a process occurs simply by “chance.” In contrast, the opposite of random is the word determined, which means the outcome of a process can be predicted by understanding a sequence of cause and effect events.

BUT WAIT! Fact: Chaos is not random!

Chaos is actually a special case of determinism. While the outcome of a chaotic process is indeed determined, the number of inputs contributing to the process is so great, that it is mathematically impossible to calculate all of the data to predict what will inevitably result. Remember the story of the butterfly effect; in which a butterfly that flaps its wings in South America influences a storm in North America?

The weather is an example of chaos. You could make a totally accurate prediction of what the weather will be at twelve-noon on Monday in Paris … but one would first have to calculate the flapping wings of every butterfly and every other insect around the world, as well as measure every breeze on the planet, and a myriad of other contributing factors. Theoretically, the collective data would be able to make an accurate prediction of weather at every spot on the globe. The problem is that it is impossible to record all of the data necessary for that accuracy. So, weather prediction, using only a small data set, would not provide an accurate prediction but would represent more of a ‘probable’ prediction.

In regard to the current global chaos, the influence of human behavior has undermined the web of life and precipitated the planet’s Sixth Mass Extinction event. Is the current chaos expressing civilization’s end or is it signaling a new beginning for civilization?

Stepping into A New Phase of Civilization

Surprise! Nature is an expression of fractal geometry, the science that emphasizes the principle of “As above, so below.” Getting to the point, the evolution of human civilization is an expression of a fractal, self-similar, image of vertebrate evolution; the pattern of evolution that went from fish to amphibians, to reptiles, birds, and finally, mammals. Human civilization has completed the first four stages and is on the threshold of manifesting the fifth level, the ‘mammalian’ version of our evolution. The earliest version of civilization represented the ‘fish’ phase, a time when the lives of the early people were tied to the proximity of water, living off the fruits of the sea and traveling the planet from coast to coast.

Once humans developed the ability to dig wells and use viaducts to control the availability of water, they were able to move on to the land and generate agriculture. This was the equivalent of the ‘amphibian’ phase of human evolution, starting at the water and moving onto land. The introduction of technology pushed humanity to the next higher level of civilization’s evolution, its ‘reptilian’ phase. Reptiles, from lizards to dinosaurs, move and behave as powerful, Earth-bound digital ‘machines.’ When humans entered the industrial age, civilization advanced beyond agriculture and created a mechanized civilization. Interestingly, the ‘blood’ of the dinosaurs, oil, is the fuel that powers our ‘reptilian’ civilization.

In 1902, the industrial revolution enabled the Wright brothers to manifest human flight in North Carolina, an event that birthed the ‘bird’ phase of civilization. Civilization’s ‘bird’ phase culminated when humans landed on the Moon in 1969. The event was marked by the astronauts’ picture of the distant blue-green planet Earth on the Moon’s horizon.

This one photograph changed human civilization and launched the Earth Day movement, a time of Hippies and a time when people began to consciously recognize that we must take care of the children, the oceans, the lands and the air … a focus on nurturing Nature. It is not a coincidence that the character of mammals is that they are, by definition, ‘nurturers.’ The moon landing, the fullest evolution of the ‘bird’ phase, precipitated the evolution of the ‘mammalian’ phase of civilization.

Opportunity for a New Beginning

The current global chaos is a symptom of the pending mass extinction event. It is an expression of an inherent fractal pattern, in which Nature is informing us that our destructive ‘reptilian’ phase of exploiting Nature must come to an end. It is necessary that the ‘reptilian’ dinosaurs, the corporations that control government, stop desecrating Mother Nature for profits. It is time for us to collectively evolve to a higher level of consciousness and adopt the indigenous people’s insight as being ‘gardeners’ that nurture the planet. Nature is now calling us to adopt our ‘mammalian’ character as nurturers.

So where are we at the current moment? The most important point we must recognize is that the current chaos is not a ‘random’ character; it is an expression of an unfolding predetermined pattern. We are observing the collapse of the current destructive ‘reptilian’ civilization while simultaneously seeing the rise of the new, nurturing ‘mammalian’ culture.

The important conclusion of this communication is that the planetary upheaval we are now experiencing is not an ending, but a new beginning, offering an opportunity to birth a new, healthy, sustainable civilization. Employing an understanding of Nature’s inherent fractal pattern will enable human beings to create a social structure that will nurture the planet and its web of life, an evolutionary uprising that will ensure all of life has a chance to thrive into the future.

The conclusion is simple: Don’t focus on the structures that are collapsing. It is time to direct our intentions and our efforts in supporting the rise of a holistic, healthy and harmonious new civilization!

Source: Uplift Connect

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